Background: Zika virus (ZIKV) infection gained public health concern after the 2015 outbreak in Brazil, when\nmicrocephaly rates increased in babies born from infected mothers. It was demonstrated that ZIKV causes a\ncongenital Zika virus syndrome, including various alterations in the development of the central nervous system.\nAlthough the infection of cells from the nervous system has been well documented, less is known in respect of\nZIKV ability to infect immune cells. Herein, we investigated if peripheral blood mononuclear cells (PBMCs), freshlyisolated\nfrom healthy donors, could be infected by ZIKV.\nMethods: PBMCs from healthy donors were isolated and cultured in medium with ZIKV strain Rio-U1 (MOI = 0.1).\nInfection was analyzed by RT-qPCR and flow cytometry���������.
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